Information from company websites and Dr. Mobeen’s Medical Lectures video.
1. The University of Oxford (UK)
Oxford Vaccine Group is now testing a vaccine developed at the same University’s Jenner Institute. They are partnering with AstraZeneca to bring this vaccine to market — IF it works out in testing.
24 April 2020: “University of Oxford researchers have begun testing a COVID-19 vaccine in human volunteers in Oxford today. Around 1,110 people will take part in the trial, half receiving the vaccine and the other half (the control group) receiving a widely available meningitis vaccine.” This is Phase I testing: “safety, side effects, best dose.”
The vaccine is a weakened chimpanzee adenovirus modified to express the SARS-CoV-2 Spike protein on its surface.
Can the vaccine infect human cells? Unknown.
mRNA vaccine — coding for the Spike protein. So the human cells see the mRNA and make the Spike protein, so that the immune system will recognize it.
Phase II now. Phase III by summer (last phase before vaccinating population).
3. Pfizer and Biontech
making 4 different vaccines of various types; some in Phase I and some in Phase II.
can make 20 million doses by end of 20 million doses by end of 2020
Phase I and II, asking for Phase III
chemically inactivated (dead) virus
successful in Resus monkeys
It looks like there will be an approved vaccine by the end of 2020. But it may take months to make millions of doses. It also looks like there will be multiple competing vaccines approved. But I doubt that any vaccine would be available to the general public in 2020 or in the early part of 2021.
I expect the vaccines to be given out to certain persons first (after testing). It will be controversial who gets the vaccine first (or second, or third, etc.) There will not be enough doses to go around for a long time.
So don’t worry that a vaccine would be mandatory. The opposite situation is more likely, that you won’t be able to get the vaccine, if you want it, just as you might not be able to get testing, even if you want or need it.
These vaccine candidates are all quick and dirty, by which I mean they are dangerous. The companies are taking the shortest route to a vaccine, which means using more dangerous means.
Coding the Spike protein into an adenovirus means that the virus might be able to infect all the same human cells as Covid-19. Spike proteins dock with the ACE2 receptor of cells in the lungs, intestines, lining of blood vessels, heart, etc. And when they dock, they break that receptor, causing an imbalance in the ACE1 – ACE2 (Renin-Angiotensin) system. If they test it and it is safe, fine, but it could mutate.
The more persons you vaccinate with a live vaccine, the greater the risk of a dangerous mutation. When you vaccinate a billion persons or more, the odds of such a dangerous mutation go up astronomically. I think the killed vaccine is a better bet, safety-wise. But a live vaccine gives better immunity. So these factors must be weighed.
Things are never going back to normal, by the way. And there will be a second wave of Covid-19 deaths and multiple societal problems, one after another. There will be other runs on the supermarkets, like the relatively minor rush to the stores that happened not too long ago. Store up supplies. Start a garden, if you can. Consider buying a firearm — which is not for everyone, by the way. And make sure you have some type of water purification equipment. Also, I would stock up on OTC medications. Things are going to get much much worse in the not too distant future.
Ronald L. Conte Jr.